Table 3a. Sensitivity, specificity, PPV, NPV, APV, TPV and RV of cytology for colposcopy outcomes (CIN2+) among women attending for a colposcopy within 12 months of their first invitation for screening.
| Measure | Vaccination | N | R | Estimate (95% CI) | P-value |
|---|---|---|---|---|---|
| Sensitivity high-grade dyskaryosis CIN2+ | Unimmunised | 807 | 604 | 74.85 (71.74, 77.72) | 0.793 |
| Fully immunised | 176 | 134 | 76.14 (69.32, 81.83) | ||
| Specificity Neg/Border/LG CIN2+ | Unimmunised | 815 | 630 | 77.30 (74.30, 80.04) | 0.950 |
| Fully immunised | 303 | 233 | 76.90 (71.83, 81.29) | ||
| PPV of high-grade dyskaryosis for CIN2+ | Unimmunised | 789 | 604 | 76.55 (73.47, 79.38) | 0.002 |
| Fully immunised | 204 | 134 | 65.69 (58.94, 71.86) | ||
| NPV Neg/Border/LG for CIN2+ | Unimmunised | 833 | 630 | 75.63 (72.60, 78.42) | 0.002 |
| Fully immunised | 275 | 233 | 84.73 (80.00, 88.50) | ||
| APV of Bl/LG for CIN2+ | Unimmunised | 759 | 179 | 23.58 (20.70, 26.73) | 0.003 |
| Fully immunised | 256 | 37 | 14.45 (10.67, 19.29) | ||
| TPV of all colp for CIN2+ | Unimmunised | 1622 | 807 | 49.75 (47.32, 52.18) | 0.000 |
| Fully immunised | 479 | 176 | 36.74 (32.55, 41.15) | ||
| RV of all colp for CIN2+ | Unimmunised | 1622 | 807 | 2.01 (1.92, 2.11) | 0.000 |
| Fully immunised | 479 | 176 | 2.72 (2.43, 3.07) |
Abbrevaitions: APV=abnormal predictive value; CI=confidence interval; CIN=cervical intraepithelial neoplasia; colp=colposcopy; NPV=negative predictive value; PPV=positive predictive value; RV=referral value; TPV=total predictive value.