Table 3b. Sensitivity, specificity, PPV, NPV, APV, TPV and RV of cytology for colposcopy outcomes (CIN3+) among women attending for a colposcopy within 12 months of their first invitation for screening.
| Measure | Vaccination | N | R | Estimate (95% CI) | P-value |
|---|---|---|---|---|---|
| Sensitivity high-grade dyskaryosis CIN3+ | Unimmunised | 351 | 288 | 82.05 (77.70, 85.71) | 0.427 |
| Fully immunised | 75 | 65 | 86.67 (77.17, 92.59) | ||
| Specificity Neg/Border/LG CIN3+ | Unimmunised | 1271 | 770 | 60.58 (57.87, 63.23) | 0.081 |
| Fully immunised | 404 | 265 | 65.59 (60.83, 70.06) | ||
| PPV of high-grade dyskaryosis for CIN3+ | Unimmunised | 789 | 288 | 36.50 (33.22, 39.92) | 0.249 |
| Fully immunised | 204 | 65 | 31.86 (25.85, 38.54) | ||
| NPV Neg/Border/LG for CIN3+ | Unimmunised | 833 | 770 | 92.44 (90.44, 94.04) | 0.033 |
| Fully immunised | 275 | 265 | 96.36 (93.44, 98.01) | ||
| APV of Bl/LG for CIN3+ | Unimmunised | 759 | 51 | 6.72 (5.15, 8.73) | 0.049 |
| Fully immunised | 256 | 8 | 3.13 (1.59, 6.04) | ||
| TPV of all colp for CIN3+ | Unimmunised | 1622 | 351 | 21.64 (19.70, 23.71) | 0.005 |
| Fully immunised | 479 | 75 | 15.66 (12.68, 19.18) | ||
| RV of all colp for CIN3+ | Unimmunised | 1622 | 351 | 4.62 (4.22, 5.08) | 0.005 |
| Fully immunised | 479 | 75 | 6.39 (5.21, 7.89) |
Abbrevaitions: APV=abnormal predictive value; CI=confidence interval; CIN=cervical intraepithelial neoplasia; colp=colposcopy; NPV=negative predictive value; PPV=positive predictive value; RV=referral value; TPV=total predictive value.