Table 2. Association between lithium use and risk of colorectal adenocarcinoma, specified by pattern of use within the entire exposure period, excluding the last year prior to the index date.
| Exposure group | Cases | Controls | Crude ORa | Adjusted ORb |
|---|---|---|---|---|
| Non-use | 36 089 | 360 909 | 1.00 (ref.) | 1.00 (ref.) |
| Ever use | 159 | 1571 | 1.01 (0.86–1.19) | 1.08 (0.92–1.28) |
| Long-term use (⩾5 years) | 78 | 734 | 1.06 (0.84–1.34) | 1.13 (0.89–1.43) |
|
Duration of use | ||||
| <1 year | 21 | 277 | 0.76 (0.49–1.18) | 0.82 (0.53–1.28) |
| 1–4.99 years | 60 | 560 | 1.07 (0.82–1.40) | 1.15 (0.88–1.50) |
| 5–9.99 years | 50 | 506 | 0.99 (0.74–1.33) | 1.06 (0.79–1.41) |
| ⩾10 years | 28 | 228 | 1.22 (0.83–1.81) | 1.29 (0.87–1.91) |
Abbreviation: OR=odds ratio.
a
Adjusted for age, calendar time and sex (by matched design).
b
Fully adjusted model, see section ‘Main analysis'.