Table 3. Relationship between MMR status and tumour microenvironment.
| Tumour microenvironment | All n=228 (%) | MMR competent n=193 (%) | dMMR n=35 (%) | P-value |
|---|---|---|---|---|
|
KM grade | ||||
| Weak | 77 (34) | 63 (33) | 14 (40) | 0.398 |
| Strong | 151 (66) | 130 (67) | 21 (60) | |
|
CD3 margin density (215) | ||||
| Low | 118 (55) | 100 (55) | 18 (56) | 0.867 |
| High | 97 (45) | 83 (45) | 14 (44) | |
|
CD3 cancer cell nest density (224) | ||||
| Low | 146 (65) | 130 (69) | 16 (46) | 0.009 |
| High | 78 (35) | 59 (31) | 19 (54) | |
|
CD8 margin density (216) | ||||
| Low | 127 (59) | 105 (57) | 22 (67) | 0.319 |
| High | 9 (41) | 78 (43) | 11 (33) | |
|
CD8 cancer cell nest density (222) | ||||
| Low | 161 (72) | 140 (75) | 21 (60) | 0.071 |
| High | 61 (28) | 47 (25) | 14 (40) | |
|
CD45R0 margin density (217) | ||||
| Low | 112 (52) | 96 (53) | 6 (47) | 0.564 |
| High | 105 (48) | 87 (47) | 18 (53) | |
|
CD45R0 cancer cell nest density (224) | ||||
| Low | 160 (71) | 141 (75) | 19 (54) | 0.015 |
| High | 64 (29) | 48 (25) | 16 (46) | |
|
FOXP3 margin density (216) | ||||
| Low | 126 (58) | 104 (57) | 22 (65) | 0.413 |
| High | 90 (42) | 78 (43) | 12 (35) | |
|
FOXP3 cancer cell nest density (219) | ||||
| Low | 110 (50) | 92 (50) | 18 (53) | 0.731 |
| High | 109 (50) | 93 (50) | 16 (47) | |
|
TSP (225) | ||||
| Low | 166 (74) | 138 (72) | 28 (85) | 0.118 |
| High | 59 (26) | 54 (28) | 5 (15) | |
Abbreviations: CRC=colorectal cancer; dMMR=mismatch repair deficient; KM=Klintrup–Mäkinen; MMR=mismatch repair; TSP=tumour stroma percentage. The relationship between MMR status and tumour microenvironment of patients undergoing elective, potentially curative resection of stage I–III CRC.