Table 4. Relationship between MMR status and systemic inflammatory responses.
| Systemic inflammatory responses | All n=228 (%) | MMR competent n=193 (%) | dMMR n=35 (%) | P-value |
|---|---|---|---|---|
|
Serum CRP | ||||
| mg l−1 | 8 (6–20) | 7 (5–18) | 21 (7–48) | <0.001 |
|
Serum albumin | ||||
| g l−1 | 40 (36–42) | 40 (37–42) | 39 (34–43) | 0.258 |
|
Modified Glasgow Prognostic Score | ||||
| 0 | 131 (58) | 117 (61) | 14 (40) | 0.007 |
| 1 | 71 (31) | 58 (30) | 13 (37) | |
| 2 | 26 (11) | 18 (9) | 8 (23) | |
|
Neutrophil count (227) | ||||
| × 109 l−1 | 5.4 (4.3–6.7) | 5.3 (4.2–6.6) | 6.4 (4.6–7.7) | 0.032 |
|
Lymphocyte count (227) | ||||
| × 109 l−1 | 1.5 (1.2–2.1) | 1.5 (1.2–2.1) | 1.6 (1.2–2.1) | 0.891 |
|
Platelet count (207) | ||||
| × 109 l−1 | 300 (245–369) | 296 (242–360) | 352 (251–441) | 0.091 |
|
Neutrophil count (227) | ||||
| ⩽7.5 × 109 l−1 | 192 (85) | 168 (87) | 24 (69) | 0.004 |
| >7.5 × 109 l−1 | 35 (15) | 24 (13) | 11 (31) | |
|
Lymphocyte count (227) | ||||
| ⩽4 × 109 l−1 | 171 (83) | 191 (99) | 35 (100) | 0.669 |
| >4 × 109 l−1 | 36 (17) | 1 (1) | 0 (0) | |
|
Platelet count (207) | ||||
| ⩽400 × 109 l−1 | 226 (99) | 150 (85) | 21 (68) | 0.018 |
| >400 × 109 l−1 | 1 (1) | 26 (15) | 10 (32) | |
|
NLR (227) | ||||
| ⩽5 | 177 (78) | 153 (80) | 24 (69) | 0.145 |
| >5 | 50 (22) | 39 (20) | 11 (31) | |
|
NPS (207) | ||||
| 0 | 149 (72) | 132 (75) | 17 (55) | 0.001 |
| 1 | 47 (23) | 39 (22) | 8 (26) | |
| 2 | 11 (5) | 5 (3) | 6 (19) | |
Abbreviations: CRC=colorectal cancer; CRP=C-reactive protein; dMMR=mismatch repair deficient; mGPS=modified Glasgow Prognostic Score; MMR=mismatch repair; NLR=neutrophil : lymphocyte ratio; NPS=neutrophil : platelet score.
The relationship between MMR status and systemic inflammatory responses of patients undergoing elective, potentially curative resection of stage I–III CRC.