Table 5. Relationship between tumour microenvironment and systemic inflammatory response characteristics.
| Multivriate analysis HR (95% CI) | P-value | |
|---|---|---|
|
All patients (n=228) | ||
| CD3 cancer cell nest density (low/high) | 0.28 (0.14–0.57) | <0.001 |
| CD45R0 cancer cell nest density (low/high) | 0.69 (0.28–1.72) | 0.430 |
| mGPS (0/1/2) | 1.59 (1.12–2.27) | 0.010 |
| NPS (0/1/2) | 1.47 (1.01–2.14) | 0.042 |
| MMR status (competent/deficient) | 0.69 (0.31–1.54) | 0.367 |
|
Stage II/Stage III only (n=212) | ||
| CD3 cancer cell nest density (low/high) | 0.30 (0.15–0.61) | 0.001 |
| CD45R0 cancer cell nest density (low/high) | 0.77 (0.30–1.95) | 0.578 |
| mGPS (0/1/2) | 1.52 (1.06–2.19) | 0.023 |
| NPS (0/1/2) | 1.46 (1.01–2.13) | 0.047 |
| MMR status (competent/deficient) | 0.71 (0.32–1.58) | 0.399 |
Abbreviations: CRC=colorectal cancer; CI=confidence interval; HR=hazard ratio; mGPS=modified Glasgow Prognostic Score; MMR=mismatch repair; NPS=neutrophil : platelet score.
The relationship between tumour microenvironment and systemic inflammatory response characteristics associated with MMR status and cancer-specific survival of patients undergoing elective, potentially curative resection of stage I–III CRC.