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. 2016 Feb 11;114(5):545–553. doi: 10.1038/bjc.2016.18

Figure 4.

Figure 4

Arpin-depleted MDA-MB-231 cells display increased migration and proliferation. (A) Two MDA-MB-231 clones stably depleted of Arpin and two clones transfected with non-targeting shRNA (shCtrl) were analysed by western blot for their Arpin content. (B) MDA-MB-231 clones stably depleted of Arpin close a wound faster than controls. Pictures were taken after 10 h of wound healing. Bar: 20 μm. (C) Growth curves of the clones. MDA-MB-231 clones stably depleted of Arpin proliferate faster than controls. (D) Transformation foci stained with crystal violet and quantification of the stain. Mean and s.e.m. are represented. Bar: 2 mm. (E) Anchorage-independent growth in soft agar. MDA-MB-231 clones stably depleted of Arpin generate larger colonies than controls. Bar: 20 μm. Mean and s.e.m. are represented.