Table 3. Enriched functional terms and proteins organising them in HGSCs.
| Terms and proteins | HGSC/EC ratio |
|---|---|
|
Negative regulation of protein metabolic process | |
| Insulin-like growth factor 2 mRNA-binding protein 2 (IMP2) | 2.691 |
| α2-Macroglobulin | 1.884 |
| Proteasome activator complex subunit 1 | 1.430 |
| Filamin-A | 1.793 |
| Proteasome activator complex subunit 2 | 1.321 |
| Heat shock protein HSP 90-β | 1.272 |
|
DNA replication initiation | |
| DNA replication licensing factor MCM2 (MCM2) | 1.549 |
| DNA replication licensing factor MCM5 | 1.494 |
| DNA replication licensing factor MCM7 | 1.419 |
Abbreviations: EC=grade 1 endometrioid carcinoma; HGSC=high-grade serous carcinoma; MCM2=DNA replication licensing factor minichromosome maintenance protein 2.
Protein ontology analysis finds two enriched terms in HGSC: ‘negative regulation of a protein metabolic process' and ‘DNA replication initiation'. Each term was organised around six and three proteins, respectively. Respectively, IMP2 and MCM2 were the most differentially expressed proteins for each term. Differential expression ratio was calculated from the mean of protein expression values of HGSC /EC samples.