Table 2.
Pregnancy outcome in studies with various therapeutic regimens
Successful continuation of pregnancy
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First author | Design | N | Sonography at presentation | Intervention | Intervention group | Controls | P value |
Mollerw11 | Randomised controlled trial | 260 | No | Medroxyprogesterone (three regimens) | 60/123 | 71/137 | 0.62 |
Tognoniw12 | Randomised controlled trial | 145 | No | Hydroxyprogesterone caproate | 49/74 | 50/71 | 0.58 |
Berlew13 | Randomised controlled trial | 300 | No | Hydroxyprogesterone caproate | 96/154 | 100/146 | 0.26 |
Gerhardw14 | Randomised controlled trial | 52 | Yes | Progesterone | 23/26 | 21/26 | 0.44 |
Soltanw16 | Randomised controlled trial | 35 | Yes | Buphenine | 19/23 | 4/12 | <0.01 |
Harrison22 | Randomised controlled trial | 61 | Yes | hCG | 14/20 | 11/21 | 0.24 |
Harrison22 | Randomised controlled trial | 61 | Yes | Bed rest | 5/20 | 11/21 | 0.07 |
Giobbe23 | Retrospective | 226 | Yes | Bed rest | 123/146 | 64/80 | 0.41 |
Ben-Haroush24 | Prospective observational | 230 | Yes | Bed rest | 180/200 | 23/30 | 0.03 |