Table 2.

Bethesda System (Last update in 2014)

Terminology	Interpretation
Negative for intraepithelial lesion or malignancy	No cellular evidence of neoplasia
Squamous cells:
Atypical squamous cells:
Of undetermined significance (ASC-US)	Undetermined
Cannot exclude HSIL (ASH-H)	Cannot exclude pre-malignant lesion
Low-grade squamous intraepithelial lesion (LSIL)	HPV/mild dysplasia/CIN-1
High-grade squamous intraepithelial lesion (HSIL)	Moderate and severe dysplasia/CIN-2 and CIN-3/SIC
Squamous cell carcinoma	Invasive cancer
Glandular cells:
Atypical glandular cells	Undetermined or cannot exclude pre-malignant lesion
Endocervical adenocarcinoma is situ	CIS
Adenocarcinoma	Invasive cancer

Abbreviations: CIN cervical intraepithelial neoplasia, CIS carcinoma in situ, HPV human papillomavirus

Adapted from Nayar and Wilbu [48]