Table 2.
The NTG-induced cardiohemodynamic alterations in different groups of rats with acute myocardial infarction
| Parameters | Animal groups | |||||
|---|---|---|---|---|---|---|
| Control (nontolerant), n = 18 | I—NTG-tolerant, n = 20 | II—NTG-tolerant + CGRP antagonist, n = 20 | ||||
| a | b | a | b | a | b | |
| BP (mmHg) | 115 ± 6 | −28.4 ± 2.5 | 109 ± 5 | −16.2 ± 1.6* | 110 ± 8 | −8.8 ± 1.2***### |
| HP (ms) | 158 ± 7 | −25.6 ± 3.8 | 151 ± 5 | −11.0 ± 1.2* | 147 ± 6 | 5.2 ± 1.4***### |
| BRS (ms/mmHg) | 0.9 ± 0.1 | 0.66 ± 0.05** | 0.58 ± 0.04** | |||
BP blood pressure, HP heart period, BRS baroreflex sensitivity, a initial values, b after NTG injection, n number of animals
Difference with the control group: *p < 0.05; **p < 0.01; ***p < 0.001; difference with the I—NTG-tolerant group: ### p < 0.001