Table 5.
Multivariate linear regression analysis of factors influencing change of creatinine clearance
| Means | Regression coefficient (95 % CI) | p value | ||
|---|---|---|---|---|
| Fluid [= HES] | 48 % | −8.2 | (−15.7 to −0.7) | 0.033 |
| Sex [= male] | 77 % | 1.7 | (−7.0 to 10.4) | 0.697 |
| Age (year) | 66 (64 to 67) | −0.4 | (−0.8 to 0.0) | 0.054 |
| BMI (kg/m2) | 22 (21 to 22) | −1.8 | (−2.7 to −0.8) | < 0.001 |
| Preoperative creatinine clearance (ml/min/1.73 m2) | 87 (83 to 91) | −0.4 | (−0.6 to −0.2) | < 0.001 |
| MAP > 70 mmHg (achievement rate during whole operation period) | 0.77 (0.74 to 0.80) | 27.9 | (5.9 to 49.8) | 0.013 |
| MAP > 70 mmHg (achievement rate during whole ICU observation) | 0.85 (0.83 to 0.88) | 19 | (−2.4 to 41) | 0.081 |
| CI > 2.5 l/min/m2 (achievement rate during whole operation period) | 0.70 (0.66 to 0.74) | −5.8 | (−22 to 10) | 0.477 |
| CI > 2.5 l/min/m2 (achievement rate during whole ICU observation) | 0.95 (0.94 to 0.96) | 16.7 | (−36.6 to 70.1) | 0.536 |
| Noradrenaline infusion ratea during operation (μg/kg/min) | 0.03 (0.02 to 0.04) | −42 | (−111 to 26) | 0.222 |
| Noradrenaline infusion ratea during ICU (μg/kg/min) | 0.02 (0.01 to 0.03) | −60 | (−126 to 5.6) | 0.073 |
| Dobutamine infusion ratea during operation (μg/kg/min) | 0.40 (0.07 to 0.73) | 1.4 | (−0.9 to 3.8) | 0.227 |
| Dobutamine infusion ratea during ICU (μg/kg/min) | 0.17 (0.02 to 0.32) | −1.7 | (−5.6 to 2.2) | 0.389 |
| GEDI > 640 ml/m2 (achievement rate during whole operation period) | 0.74 (0.69 to 0.79) | −9.2 | (−26.9 to 8.4) | 0.302 |
| GEDI > 640 ml/m2 (achievement rate during whole ICU observation) | 0.80 (0.76 to 0.85) | 20 | (2.3 to 37) | 0.027 |
| ELWI < 11 ml/kg (achievement rate during whole operation period) | 0.89 (0.86 to 0.93) | 15 | (−1.8 to 31) | 0.079 |
| ELWI < 11 ml/kg (achievement rate during whole ICU observation) | 0.93 (0.90 to 0.96) | −3.2 | (−24 to 18) | 0.764 |
Means are given as percentage of all patients, mean of all patients (95 % confidence interval) or mean of the ratio the respective parameter was within the target range relating to the complete observation period of all patients (95 % confidence interval)
CI confidence interval, HES hydroxyethyl starch, BMI body mass index, MAP mean arterial pressure, ICU intensive care unit, CI cardiac index, GEDI global end-diastolic index, ELWI extravascular lung water index
aMean individual infusion rate