Table 2.

Change in anxiety during treatment (mITT population)

Measure	Baseline	Week 12	Week 24
Hospital anxiety and depression scale
Anxiety subscale score (range 0–21)	7.0 ± 4.1	5.8 ± 4.3*	5.9 ± 4.1*
State–trait anxiety inventory
State anxiety subscale (range 20–80)	40.4 ± 12.3	35.9 ± 12.7*	36.6 ± 12.9*
Trait anxiety subscale (range 20–80)	38.8 ± 10.9	36.7 ± 12.1*	37.6 ± 12.1

* p < 0.005 by comparison to baseline, as calculated by a paired t-test

mITT modified intent-to-treat