Table 3.
Tumor biologic factors correlating with the intestinal subtype
| Parameter | Subtype | Correlation with INT | |||
|---|---|---|---|---|---|
| INT | PB | POOR | CC | p | |
| CK7 % | 70 (0–100) | 90 (5–100) | 40 (0–90) | -0.24 | 0.148 |
| CK20 % | 90 (0–100) | 5 (0–100) | 2.5 (0–10) | 0.47 | 0.003 |
| CDX2 % | 90 (20–100) | 10 (0–80) | 45 (0–100) | 0.69 | 0.000 |
| ZEB1 % | 0 (0–2) | 0 (0–16) | 2 (0–3) | -0.32 | 0.046 |
| VIM % | 0 (0–10) | 0 (0–10) | 0 (0–0) | 0.02 | 0.914 |
| ECad % | 100 (50–100) | 100 (75–100) | 75 (50–100) | 0.03 | 0.869 |
| Budding | 8 (0–35) | 15 (2–46) | 43 (6–66) | -0.46 | 0.003 |
| CAF | 1 (0–2) | 2 (0–2) | 0.5 (0–1) | -0.34 | 0.035 |
CC and p values derived from two-sided Spearman rank correlation. % expression in percentage of tumor cells, Tumor budding measured as number of tumor buds per HPF (high power field)
Abbreviations: INT intestinal, PB pancreatobiliary, POOR poorly differentiated, CC correlation coefficient, KRT cytokeratin staining, CDX2 caudal type homeobox 2, ZEB1 zinc finger and homeobox 1, ECad E-Cadherin, CAF cancer associated fibroblast activation