Table 5.
Gene Ontology (GO) functional enrichment analysis regulated proteins in ampullary cancer cells MDA-AMP7, AVC1, RCB1280 and SNU487
| GO terms of up-regulated proteins | Count | FDR |
| GO:0065007 Biological regulation | 93 | 1.41E-02 |
| GO:0071840 Cellular component organization or biogenesis | 67 | 2.08E-06 |
| GO:0051179 Localization | 54 | 5.18E-04 |
| GO:0016071 mRNA metabolic process | 42 | 9.87E-23 |
| GO:0032268 Regulation of cellular protein metabolic process | 44 | 5.73E-11 |
| GO:0050896 Response to stimulus | 75 | 1.09E-02 |
| GO terms of down-regulated proteins | Count | FDR |
| GO:0008152 Metabolic process | 98 | 9.97E-04 |
| GO:0009987 Cellular process | 119 | 3.15E-03 |
| GO:0044237 Cellular metabolic process | 113 | 4.87E-11 |
| GO:0009117 Nucleotide metabolic process | 37 | 2.96E-12 |
| GO:0016310 Phosphorylation | 22 | 2.60E-03 |
| GO:0006629 Lipid metabolic process | 24 | 5.66E-04 |
Enrichment is analyzed using all differentially expressed proteins with fold-change of greater than 50 % in MDA-AMP7, AVC1, RCB1280 and SNU487 cells cultivated in CAF-conditioned medium versus non-treated control cells (log2 ratio of > 0.58, p-value < 0.1, two-tailed t-test, FDR < 0.05)
Abbreviations: CAF cancer associated fibroblast, FDR false discovery rate