Table 1.
Overview of the behavioral tests per batch
Age | Task | Batch | Subjects (n) |
---|---|---|---|
3 weeks | Juvenile social interaction | Batch 1 + 2 | 6–7 genotype-matched pairs per genotype |
4 weeks | Extended SHIRPA screen | Batch 1 + 2 | 19–26 per genotype |
6 weeks | Extended SHIRPA screen | Batch 1 + 2 | 19–26 per genotype |
8 weeks | Extended SHIRPA screen | Batch 1 + 2 | 19–26 per genotype |
Adult | Extended SHIRPA screen | Batch 1 | 10–15 per genotype |
Open field | Batch 1 | 10–15 per genotype | |
Elevated plus maze | Batch 1 | 10–15 per genotype | |
Social discrimination | Batch 1 | 10–15 per genotype | |
Buried food test | Batch 2 | 9–11 per genotype | |
Set shifting-reversal task | Batch 2 | 9–11 per genotype | |
Social approach in 3-chamber | Batch 3 | 12 per genotype | |
Novel object exploration task | Batch 3 | 12 per genotype | |
Barnes maze-reversal task | Batch 4 | 16 per genotype | |
Pre-pulse inhibition | Batch 4 | 16 per genotype |
Animals in batch 1 + 2 were weaned at post-natal day 21. Batch 3 + 4 animals were weaned at post-natal day 28