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. 2016 Mar 8;14:67. doi: 10.1186/s12967-016-0814-z

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© Babichev et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — BEZ235 inhibits PI3K/mTOR pathway downstream effectors in LMS cells. Immunoblot demonstrates decreased levels of p-AKT^S473 and of p-4EBP1^T37/46 in total lysates from SKLMS1 and STS39 cells treated with BEZ235 for 72 h at concentrations ranging from 0 to 1000 nM/L. Total AKT, 4EBP1 and tubulin levels demonstrate equal loading of protein lysates