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. Author manuscript; available in PMC: 2016 Mar 8.
Published in final edited form as: Science. 2015 Aug 14;349(6249):742–747. doi: 10.1126/science.aaa8391

Fig. 2. Mutagenesis in wild-type cells is restricted to the vicinity of the broken replication fork.

Fig. 2

(A) Positions of URA3 reporter genes with respect to broken forks. (B) Diagram of possible recombination template switches leading to gene conversion. (C and D) Median 5-FOAR break–induced (+FLP) and spontaneous (−FLP) mutation rates in wild-type cells (C) without or (D) with ura3-1 on ChrV. Error bars show 1 SD, and significant increases over spontaneous are indicated. *P < 0.05, **P < 0.01, ***P < 0.001. (E) Estimated rates of point mutations, GCRs, and ura3-1 conversions. Fold changes above spontaneous are indicated.