Figure 2.

Effect of co-ultraPEALut on cell proliferation in spinal cord of SCI mice. (A) BrdU (70 mg/kg, i.p.) was given 2 h before sacrifice to examine the effects of 72 h co-ultraPEALut administration. In SCI-operated mice the number of proliferating cells increased at 72 h. Moreover, co-ultraPEALut treatment further increased this number. Values are mean ± SEM (N = 10 per group). (^*p < 0.05 vs. sham group; ^#p < 0.05 vs. SCI group). (C) BrdU⁺ nuclei in sham group (D), BrdU⁺ nuclei in SCI-operated mice (E), BrdU⁺ nuclei in co-ultraPEALut treatment. (B) In SCI-operated mice the number of DCX⁺ cells increased at 72 h; the number of DCX⁺ cells is increased after co-ultraPEALut treatment. Values are mean ± SEM (N = 10 per group; ^*p < 0.05 vs. sham group; ^#p < 0.05 vs. SCI group). (F) DCX⁺ cells in sham group at 20X magnification, (G) DCX⁺ cells in SCI-operated mice (H) DCX⁺ cells in co-ultraPEALut treatment group. All images are at 20X magnification.