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. 2014 Oct 30;52(10):993–1004. doi: 10.3109/15563650.2014.973572

Table 4.

Criteria of dialyzability.

  Primary criteria Alternative criteria 1 Alternative criteria 2 Alternative criteria 3
DialyzabilityA % RemovedB CLECTR/CLTOT (%)C T1/2 ECTR/T1/2 (%) ReECTR/ReTOT (%)C
D, Dialyzable > 30 > 75 < 25 > 75
M, Moderately dialyzable > 10–30 > 50–75 > 25–50 > 50–75
S, Slightly dialyzable ≥ 3–10 ≥ 25–50 ≥ 50–75 ≥ 25–50
N, Not dialyzable < 3 < 25 > 75 < 25

AApplicable to all modalities of ECTR, including hemodialysis, hemoperfusion, and hemofiltration.

BCorresponds to % removal of ingested dose or total body burden in a 6-hour ECTR period.

CMeasured during the same period of time.

ECTR = Extracorporeal treatment, CLECTR = Extracorporeal clearance, CLTOT = Total clearance, REECTR = Extracorporeal removal, RETOT = Total removal, T1/2 ECTR = Half-life with ECTR, T1/2 = Half-life without ECTR.

*These criteria should only be applied if measured or calculated (not reported) endogenous half-life is > 4h (otherwise, ECTR is not considered clinically relevant). Furthermore, the primary criteria are preferred for poisons having a large Vd (> 5 L/Kg).

Reproduced with permission from Clinical Toxicology