Table 4.
Primary criteria | Alternative criteria 1 | Alternative criteria 2 | Alternative criteria 3 | |
---|---|---|---|---|
DialyzabilityA | % RemovedB | CLECTR/CLTOT (%)C | T1/2 ECTR/T1/2 (%) | ReECTR/ReTOT (%)C |
D, Dialyzable | > 30 | > 75 | < 25 | > 75 |
M, Moderately dialyzable | > 10–30 | > 50–75 | > 25–50 | > 50–75 |
S, Slightly dialyzable | ≥ 3–10 | ≥ 25–50 | ≥ 50–75 | ≥ 25–50 |
N, Not dialyzable | < 3 | < 25 | > 75 | < 25 |
AApplicable to all modalities of ECTR, including hemodialysis, hemoperfusion, and hemofiltration.
BCorresponds to % removal of ingested dose or total body burden in a 6-hour ECTR period.
CMeasured during the same period of time.
ECTR = Extracorporeal treatment, CLECTR = Extracorporeal clearance, CLTOT = Total clearance, REECTR = Extracorporeal removal, RETOT = Total removal, T1/2 ECTR = Half-life with ECTR, T1/2 = Half-life without ECTR.
*These criteria should only be applied if measured or calculated (not reported) endogenous half-life is > 4h (otherwise, ECTR is not considered clinically relevant). Furthermore, the primary criteria are preferred for poisons having a large Vd (> 5 L/Kg).
Reproduced with permission from Clinical Toxicology