Supplementary Fig. 4.

Longitudinal volume changes, extracted from the high-resolution structural images, after (A and B) 3.5 months and (C and D) 4.5 months doxycycline treatment. Results are shown for (A and C) absolute volume and (B and D) normalized volume in the thalamus. Statistically significant groups have been identified and highlighted. Error bars represent the standard deviation. Wild-type versus untreated rTg4510s: *p ≤ .05, **p ≤ .01, and ****p ≤ .0001. Wild-type versus treated rTg4510s: +p ≤ .05, ++p ≤ .01, and +++p ≤ .001.