Fig. 1.

Immunohistochemistry to estimate regional tau phosphorylated at serine 409 (PG-5)–positive neurofibrillary tangle (NFT) density. (A) Representative coronal slice illustrating the distribution of PG-5 positive NFTs in the untreated rTg4510s, with visible regional specificity in treated and untreated animals. Quantitative regional estimates of cortical (B), hippocampal (C), and thalamic (D) NFT density for each of the wild-type (n = 21), untreated rTg4510s (n = 20), 4.5 months intervention Tg4510s (n = 6), and 3.5 months intervention rTg4510s (n = 10) at 7.5 months of age. The y axis has been independently adjusted for each region under investigation to account for the marked range in PG-5 density. Error bars represent the standard deviation. **p ≤ .01 and ****p ≤ .0001.