Fig. 3.

Longitudinal volumetric changes, extracted from the high-resolution structural images. Hippocampal and cortical volumes were averaged to extract absolute and normalized volume changes in the high-ranked pathology regions. We present the absolute volume changes within the high-ranked pathology regions after (A) 3.5 months and (C) 4.5 months intervention. In addition, we normalized the absolute volume changes to the total brain volume to extract the normalized volume changes after (B) 3.5 months and (D) 4.5 months intervention. Statistically significant groups have been identified and highlighted. Error bars represent the standard deviation. Wild-type versus untreated rTg4510s: **p ≤ .01, ***p < .001, and ****p ≤ .0001. Wild-type versus treated rTg4510s: +p ≤ .05 and ++++p ≤ .0001. Treated rTg4510s versus untreated rTg4510s: −−p ≤ .01 and −−−−p ≤ .0001.