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. 2016 Mar;39:184–194. doi: 10.1016/j.neurobiolaging.2015.12.001

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© 2016 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 5 — Longitudinal (A and C) fractional anisotropy and (B and D) mean diffusivity in the high-ranked pathology regions after (A and B) 3.5 months and (C and D) 4.5 months doxycycline intervention. Statistically significant groups have been identified and highlighted. Error bars represent the standard deviation. Wild-type versus untreated rTg4510s: **p ≤ .01, ***p ≤ .001, and ****p ≤ .0001. Wild-type versus treated rTg4510s: +p ≤ .05. Treated rTg4510s versus untreated rTg4510s: −−−p ≤ .001 and −−−−p ≤ .0001.