Table 4. Multivariate analysis of prognostic factors in patients with NK/T-cell lymphoma.
| Variable | OS | PFS | ||
|---|---|---|---|---|
| HR (95% CI)a | P value | HR (95% CI)a | P value | |
| Age (>60 vs. ≤60 years) | 2.82 (1.80–4.41) | 0.000 | 1.87 (1.23–2.84) | 0.004 |
| ECOG score (≥2 vs. 0–1) | 2.18 (1.29–3.67) | 0.004 | 1.56 (1.02–2.40) | 0.040 |
| Primary site (EUAT vs. UAT) | 2.34 (1.29–4.22) | 0.005 | – | – |
| Stage (III–IV vs. I–II) | – | – | – | – |
| B symptoms (yes vs. no) | – | – | – | – |
| LDH (elevated vs. normal) | 1.54 (1.01–2.36) | 0.047 | – | – |
| Involvement of regional lymph nodes | – | – | 1.56 (1.10–2.20) | 0.013 |
| Extranodal sites (≥2 vs. 0–1) | 2.14 (1.31–3.50) | 0.002 | 2.50 (1.60–3.91) | 0.000 |
| AGR (<1.3 vs. ≥1.3) | 1.74 (1.18–2.56) | 0.005 | 1.73 (1.21–2.48) | 0.003 |
| Lymphocyte count (k/cc) | 0.69 (0.51–0.92) | 0.012 | 0.75 (0.58–0.97) | 0.028 |
| Treatment (chemo alone vs. RT ± chemo) | 2.88 (1.90–4.36) | 0.000 | 2.61 (1.81–3.75) | 0.000 |
| Chemotherapeutic regimens (anthracycline-based vs. ASP-containing) | 2.32 (1.51–3.56) | 0.000 | 2.51 (1.71–3.69) | 0.000 |
Notes.
a
The hazard ratio gives the increase in risk for each unit increase for the continuous variables and gives the increased risk relative to the reference category for the categorical variables.
- AGR
- albumin to globulin ration
- ASP
- asparaginase
- CI
- confidence interval
- ECOG
- Eastern Cooperative Oncology Group
- EUAT
- extra-upper aerodigestive tract
- HR
- hazard ratio
- LDH
- lactate dehydrogenase
- OS
- overall survival
- PFS
- progression free survival
- RT
- radiotherapy
- UAT
- upper aerodigestive tract