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Summary of in vitro receptor binding and in vivo tail-flick analgesia.
| Cmpd. | MOR-CHO | DOR-CHO | KOR-CHO | ED50 (mg/kg) |
|---|---|---|---|---|
| 20 | 10.3 ± 5.1 | >100 | 87.6 ± 29 | 0.78 ± 0.26 |
| 21 | 29.4 ± 15 | 90.7 ± 23 | >100 | 9.92 ± 0.08 |
| 22 | 0.84 ± 0.34 | 2.65 ± 0.32 | 0.44 ± 0.05 | 3.10 ± 0.19 |
| 23 | 2.66 ± 1.3 | 8.90 ± 7.7 | >100 | 10.0 ± 0.00 |
| 24 | 21.1 ± 11 | 87.9 ± 4.8 | >100 | >10 |
| 25 | 2.73 ± 2.2 | 71.2 ± 8.7 | >100 | 1.09 ± 0.05 |
| 26 | 27.0 ± 20 | 27.0 ± 3.6 | >100 | >10 |
| 27 | 25.0 ± 9.8 | 8.83 ± 0.63 | >100 | >10 |
| 28 | >100 | >100 | >100 | >10 |
| 29 | >100 | >100 | >100 | >10 |
