Table 4.

Association of pre-dialysis serum sodium, SUN and serum glucose and with intra-dialytic SBP decline

	Intradialytic SBP decline per 1-mmol/L greater predialysis serum sodium	Intradialytic SBP decline per 2.8-mg/dL greater predialysis SUN	Intradialytic SBP decline per 18-mg/dL greater predialysis serum glucose
Unadjusted model	0.00 (−0.20 to 0.20); P=0.9	0.33 (0.24 to 0.42); P<0.001	0.50 (0.33 to 0.67); P<0.001
Model 1	−0.25 (−0.43 to −0.08); P=0.01	0.31 (0.23 to 0.39); P<0.001	0.18 (0.03 to 0.33); P=0.02
Model 2	−0.22 (−0.40 to −0.04); P=0.02	0.33 (0.25 to 0.42); P<0.001	0.19 (0.04 to 0.34); P=0.01
Model 2A	−0.26 (−0.48 to −0.05); P=0.02	0.29 (0.19 to 0.39); P<0.001	−0.09 (−0.62 to 0.44); P=0.74
Model 3	−0.22 (−0.40 to −0.04); P=0.02	0.33 (0.25 to 0.42); P<0.001	0.20 (0.05 to 0.35); P=0.01
Lower dialysate sodium	−0.14 (−0.35 to 0.06); P=0.2	0.34 (0.24 to 0.43); P<0.001	0.26 (0.10 to 0.42); P=0.002
Higher dialysate sodium	−0.46 (−0.85 to −0.09); P=0.02	0.35 (0.15 to 0.54); P<0.001	−0.07 (−0.42 to 0.27); P=0.7

Note: Values are provided in mm Hg; values in parentheses are 95% confidence intervals. Generalized linear models were fit to estimate the association of pre-dialysis sodium, SUN and glucose with intra-dialytic SBP decline. Model 1 additionally adjusted for age, sex, race (black versus non-black), diabetes, ischemic heart disease, congestive heart failure, access type (fistula, graft, catheter), pre-dialysis SBP and ultrafiltration rate. Model 2 adjusted for the same variables as Model 1 in addition to serum calcium, albumin, and bicarbonate. Model 2A excluded those with pre-dialysis serum glucose >132 mg/dL. Model 3 adjusted for the same variables as Model 2, in addition to dialysate sodium use (≤140 mmol/L vs. >140 mmol/L or modeling).

SBP, systolic blood pressure; SUN, serum urea nitrogen