Table 5.

Association of pre-dialysis serum sodium, SUN, and serum glucose with intra-dialytic hypotension

	Odds of intradialytic SBP per 1-mmol/L greater predialysis serum sodium	Odds of intradialytic SBP per 2.8-mg/dL greater predialysis SUN	Odds of intradialytic SBP per 18-mg/dL greater predialysis serum glucose
Unadjusted	0.99 (0.98 to 1.00); P=0.2	1.02 (1.01 to 1.02); P<0.001	1.03 (1.02 to 1.04); P<0.001
Model 1	0.98 (0.96 to 0.99); P=0.001	1.02 (1.01 to 1.03); P<0.001	1.02 (1.00 to 1.03); P=0.01
Model 2	0.98 (0.97 to 0.99); P=0.01	1.02 (1.02 to 1.03); P<0.001	1.02 (1.00 to 1.03); P=0.01
Model 2A	0.98 (0.96 to 0.99); P=0.01	1.02 (1.01 to 1.03); P<0.001	1.00 (0.96 to 1.05); P=0.9
Model 3	0.98 (0.97 to 1.00); P=0.01	1.02 (1.02 to 1.03); P<0.001	1.02 (1.01 to 1.03); P<0.001
Lower dialysate sodium	0.99 (0.97 to 1.00); P=0.06	1.02 (1.02 to 1.03); P<0.001	1.02 (1.00 to 1.03); P=0.01
Higher dialysate sodium	0.97 (0.94 to 0.99); P=0.02	1.02 (1.00 to 1.03); P=0.02	1.02 (0.99 to 1.05); P=0.3

Note: Values in parentheses are 95% confidence intervals. Generalized linear models were fit to estimate the association of pre-dialysis sodium, BUN and glucose with intra-dialytic hypotension (decline in SBP >35 mmHg, or any intra-dialytic SBP <90 mmHg). Model 1 additionally adjusted for age, sex, race (black versus non-black), diabetes, ischemic heart disease, congestive heart failure, access type (fistula, graft, catheter), pre-dialysis SBP and ultrafiltration rate. Model 2 adjusted for the same variables as Model 1 in addition to serum calcium, albumin, and bicarbonate. Model 2A excluded those with pre-dialysis serum glucose >132 mg/dL. Model 3 adjusted for the same variables as Model 2, in addition to dialysate sodium use (≤140 mmol/L vs. >140 mmol/L or modeling).

SBP, systolic blood pressure; SUN, serum urea nitrogen