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. 2014 Dec 10;1:14003. doi: 10.1038/mto.2014.3

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Copyright © 2014 The American Society of Gene & Cell Therapy

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Clonal expansion of chimeric antigen receptor-transduced T cells (CART) cells after tumor contact. (a) Proliferation. CAR-transduced T cells or untransduced T cells (LAK) were plated with irradiated tumor cells (CAIX⁺ sk-rc-52 and CAIX⁻ sk-rc-59) weekly at three different ratios of tumor to T cells as indicated. Number of T cells was counted every 3–4 days in triplicate from two separate wells. Similar results were obtained in two experiments. (b) Clonal enrichment. In tumor stimulation experiments, cultures from CART⁻ and LAK cells were assayed on 1 week and 2 weeks by flow cytometry for expression of CART and (c) T-cell subsets. One representative of two results is shown.