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. 2014 Dec 10;1:14003. doi: 10.1038/mto.2014.3

Figure 5.

Figure 5

Regression of established human renal cell carcinoma (RCC) xenografts by chimeric antigen receptor-transduced T cells (CART) cells. Athymic null mice were inoculated subcutaneously with 7.5 × 106 sk-rc-52 and 5 × 106 sk-rc-59 RCC tumor cells at left and right flank respectively. After 6 days of tumor implantation, mice were injected intravenously with 50 × 106 G36 CD28 CART cells, A8 CD28 CART cells (≥ 20% CAR+), LAK, or phosphate-buffered saline alone. High dose of IL-2 (1 × 105 U/ml) was injected every 2–3 days. Tumor size was measured by caliper every 2–3 days. Experiment 1, n = 7 and experiment 2, n = 8. Tumor size of these two experiments was shown separately. +P < 0.05; *P < 0.01; **P < 0.001 in groups of G36 Tandem-treated mice versus control no T-cell-treated mice in these two trials. Other statistic calculations are reported in the text.