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. 2014 Dec 10;1:14005. doi: 10.1038/mto.2014.5

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Copyright © 2014 American Society of Gene & Cell Therapy

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Space filling models show infection voids. The need for three-dimensional (3D) imaging is made clear when comparing tumors from multiple animals. (a/d) Immunohistochemical staining of tumors shows extensive vesicular stomatitis virus (VSV) infection (anti-VSV, green) throughout the tumor (Hoechst, blue). (b/e) Singular microSPECT/computed tomography (CT) planes taken at the same relative position within the same tumors as those stained in a/d show similar distribution relative to each other (top) but different planes through the same tumors at another location show different distributions. (c/f) 3D space filling allows differences in distribution to be clearly appreciated where tumor on top has decreased voids compared to tumor on bottom.