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. 2015 Feb 18;2:15001. doi: 10.1038/mto.2015.1

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Copyright © 2015 American Society of Gene & Cell Therapy

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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hCEA-targeted CRAd specifically kills hCEA positive tumor cells and mitigates off-target cytotoxicity. Human colorectal adenocarcinoma LS174T, pancreatic carcinoma HS766T, glioma U118MG and U118-hCAR cancer cells were infected with 1 × 10³ vp per cell of Ad.CXCR4E1.B2, control vector Ad.CXCR4E1 or wild-type Ad5. Cytotoxicity was determined at 120 hours after infection using a crystal violet staining assay. Number of viable cells is given as percentage of the cell number of uninfected control. The hCEA and hCAR expression status of the cell lines is as follows: LS174T: hCEA(+)/hCAR(+); HS766T: hCEA(+)/hCAR(−); U118MG: hCEA(−)/hCAR(−); U118-hCAR: hCEA(−)/hCAR(+). Data are presented as mean ± SD (*P < 0.05 versus U118MG cells; ^#P < 0.01 versus U118MG cells).