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. 2015 Feb 18;2:15001. doi: 10.1038/mto.2015.1

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Copyright © 2015 American Society of Gene & Cell Therapy

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Ad.CXCR4E1.B2 induces hCEA-dependent and hCAR-independent oncolysis. (a) Human colorectal adenocarcinoma LS174T cells were preincubated with soluble Ad5 knob protein at indicated concentrations and infected with 2 × 10³ vp per cell of Ad.CXCR4E1.B2 or Ad.CXCR4E1. Cytotoxicity was determined at 120 hours after infection using a crystal violet staining assay. Number of viable cells is given as percentage of the cell number of uninfected samples. Data are presented as mean ± SD (*P < 0.01 versus no treatment). (b) Inhibition of Ad.CXCR4E1.B2 mediated cytotoxicity. Ad.CXCR4E1.B2 and Ad.CXCR4E1 were incubated with hCEA at indicated concentrations. LS174T cells were infected with 2 × 10³ vp per cell of Ad.CXCR4E1.B2 or Ad.CXCR4E1. Cytotoxicity was determined at 120 hours after infection using a crystal violet staining assay. Number of viable cells is given as percentage of the cell number of uninfected samples. Data are presented as mean ± SD (*P < 0.05 versus uninfected).