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. 2015 Jan 21;1:14010. doi: 10.1038/mto.2014.10

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Copyright © 2015 American Society of Gene & Cell Therapy

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Mouse sarcoma models display baseline and virus-induced differences in tumor infiltrating lymphocyte and myeloid cell populations. Mouse sarcoma cell lines were implanted subcutaneously into the flanks of female C57Bl/6 mice. A single dose of PBS control or 1 × 10⁸ pfu of rRp450 was delivered by fractionated intratumoral injection. Seven days postinfection, (a,b) tumor-infiltrating T-cell populations were analyzed by flow cytometry. (c) Tumor-associated myeloid cell populations were analyzed 72 hours postinfection. Error bars, SD (n = 5).