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. 2015 Sep 23;2:15013. doi: 10.1038/mto.2015.13

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Copyright © 2015 Official journal of the American Society of Gene & Cell Therapy

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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Reattached epithelial ovarian cancer (EOC) spheroids are susceptible to MRBV infection. (a) Schematic representation of the infection of reattached spheroids. (b) HEYA8, SKOV3, and OVCAR8 cells were seeded to form spheroids, transferred to adherent culture to attach and disperse for 72 hours, and then infected with MYXV, vvDD, or MRBV. Bright field and fluorescence images were captured at 24 hours postinfection and images were merged using Adobe Photoshop software. (c) After 72 hours of infection, SKOV3 and HEYA8 spheroids and dispersing cells are completely eradicated by MRBV infection, yet OVCAR8 spheroids and dispersing cells exhibit less oncolytic-mediated cell death. Infection by vvDD is more effective to reduce viable cells than MYXV for all reattached spheroids. Scale bar: 1 mm. MYXV, Myxoma virus.