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. 2015 Sep 9;2:15014. doi: 10.1038/mto.2015.14

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Copyright © 2015 Official journal of the American Society of Gene & Cell Therapy

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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Dose titration of OV-loading. (a) Murine T cells or (b) human T cells engineered with CAR-negative (CAR-’ve) vectors were loaded with the indicated MOI of either VSVΔM51-GFP or vvDD-GFP, washed, and incubated with D2F2 tumor cells to test OV deposition. Relative fluorescence determined by Image Quant software and is presented as mean ± SEM from at least 2–3 replicates, normalized to tumor-only wells. CAR, chimeric antigen receptor; MOI, multiplicity of infection; OV, oncolytic virus; VSV, vesicular stomatitis virus; vvDD, “double-deleted” vaccina virus.