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. Author manuscript; available in PMC: 2016 Mar 8.
Published in final edited form as: Cell Rep. 2015 Nov 12;13(8):1589–1597. doi: 10.1016/j.celrep.2015.10.026

Figure 3. IDO1 activity and Th17 cell dynamics associate with loss of gut-resident Lactobacillus.

Figure 3

A) The abundance of Lactobacillus genus correlates strongly with IDO1 activity as measured by Kyn:Trp ratios in peripheral blood. Linear mixed effects (LME) modeling was used to allow for inclusion of longitudinal data from each animal and to test for correlations between all detected bacterial families and IDO1 activity (peripheral blood Kyn:Trp ratios). Linear regression lines are shown in black.

B) IDO1 activity (Kyn:Trp) correlates strongly and significantly with Th17 cell abundances in peripheral blood of RM, using LME modeling.

C) Lactobacillus abundance correlates with Th17 cell abundance in peripheral blood. As with B), LME modeling was used to test for correlations between all bacterial families detected and peripheral blood Th17 cell abundance, as assessed by flow cytometry gating the percentage of IL-17+ of total CD4+ cells. See also Table S2.