Fig 3. LY2624587 inhibits SDF-1 and CXCR4-mediated cell signaling in tumor cells.

Human leukemia CCRF-CEM (A) and NHL Namalwa cells (B)were treated with 100 ng/ml SDF-1 for 10 min in the presence of different concentrations of LY2624587 (CXCR4AB) or control isotype IgG (hIgG4). Western blot analysis of phospho-ERK, phospho-AKT, total ERK or actin was conducted as described under the “Materials and Methods.”