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. 2016 Mar 8;11(3):e0150585. doi: 10.1371/journal.pone.0150585

Fig 4. LY2624587 induces apoptosis of hematologic tumor cells in vitro.

Fig 4

A. Annexin V analysis by flow cytometry in NHL Namalwa cells. Namalwa cells were treated with isotype IgG (hIgG4) or LY2624587 (CXCR4 AB 93–6) for 48 h, then subjected to flow cytometry analysis utilizing FITC-conjugated annexin V. B. DNA fragmentation and cleaved caspase 3 analysis by cellomics analysis in NHL Namalwa cells. The cells were treated for 48 h in the growth medium with 10 μg/ml control IgG or LY2624587 (CXCR4 ab). C. DNA fragmentation and cleaved caspase 3 analysis by cellomics analysis in leukemia CCRF-CEM cells. The cells were treated for 96 h in growth medium with 10 μg/ml control IgG or LY2624587 (CXCR4 ab). The inserts are amplified single cells to show DNA fragmentation or caspase 3 staining.