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. 2016 Mar 8;11(3):e0151026. doi: 10.1371/journal.pone.0151026

Fig 4. PARP-1 is less inducible in MUTYH-/-MEF cell by MNNG and frataxin siRNA.

Fig 4

(A) Western blot of PARP-1 in MEF cells showed that MNNG treatment induced higher level of PARP-1 in WT MEF cells and in MUTYH-/- MEF cells expressing human MUTYH (labeled as hMUTYH) compared to MUTYH -/- MEF cells. Data represent the densitometry results of the western blots. Data are expressed as mean± s.e.m. (one way ANOVA, * p<0.05, ** p < 0.01, n = 3)(B) Western blot of PARP-1 in MEF cells showed that frataxin siRNA transfection induced higher level of PARP-1 in WT MEF cells and in MUTYH-/- MEF cells expressing human MUTYH (labeled as hMUTYH) compared to MUTYH -/- MEF cells. Data represent the densitometry results of the western blots. Data are expressed as mean± s.e.m. (t test, * p<0.05, n = 3).