| Ivermectin |
0.98 |
antiparasitic |
GABRB3, GLRA3, CYP3A4, ABCB1, ABCC1, ABCC2, ABCG2 |
- |
Glioblastoma,Lung,Colon,melanoma [49],ovarian [50] |
| Trifluridine |
0.98 |
antiviral |
PARP1, CASP3, CASP8, CASP9, CTSB, TYMS |
O [51] |
colorectal [52] |
| Astemizole |
0.97 |
antihistamine |
CYP2D6, CYP2J2, CYP3A4, HRH1, ICAM1, IGF1, IL1B, KCNH1, KCNH2, KCNQ2, KCNQ3, MAPT, ABCB1, VCAM1, ABCB11 |
O [53] |
medulloblastoma [54],melanoma [55] |
| Amlodipine |
0.95 |
blood pressure, prevent chest pain |
CACNA1C, CACNA1D, CACNA1F, CACNA1S |
O [56] |
epidermoid [57],breast [58] |
| Maprotiline |
0.95 |
antidepressant |
ADRA1A, CHRM1,CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD5, HRH1, KCNH2, SLC6A2 |
+ |
Burkitt lymphoma [59],prostate [60] |
| Apomorphine |
0.94 |
heroin addiction |
ADRA2A, ADRA2B, ADRA2C, AVP, COMT, DRD1, DRD2, DRD3, DRD4, DRD5, GH1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, JUN, MAPT, TH, CALY |
O [61] |
Glioma,Melanoma, meningioma [62] |
| Mometasone |
0.92 |
inflammation |
CSF2, CYP2C8, NR3C1, IL1B, IL10, PGR, ABCB1, TNF, VCAM1, ABCG2 |
+ |
None |
| Nortriptyline |
0.91 |
antidepressant |
SLC6A2, SLC6A4 |
O [63] |
glioma [64],melanoma [65] |
