. Author manuscript; available in PMC: 2016 May 18.

Published in final edited form as: Int J Obes (Lond). 2015 Sep 22;40(3):411–416. doi: 10.1038/ijo.2015.190

Table 3.

Mediation effect of TSS on the association of FTO (rs9939609) with BMI.

		Point Estimate	95% CI	P-value
FHS Offspring	Indirect Effect (FTO→TSS→BMI)	0.013	0.001, 0.033	0.02
	Direct Effect (FTO →BMI)	0.413	0.166, 0.658	<0.01
	Total effect	0.427	0.183, 0.671	<0.01
	Proportion of Total Effect by mediation	0.031	0.002,0.113	0.02
FHS 3^rd Gen.	Indirect Effect (FTO→TSS→BMI)	0.021	0.003, 0.43	0.03
	Direct Effect (FTO →BMI)	0.454	0.211,0.684	<0.01
	Total effect	0.475	0.224,0.703	<0.01
	Proportion of Total Effect by mediation	0.044	0.008, 0.119	0.03
WHI AA	Indirect Effect	0.015	-0.015, 0.005	0.29
	Direct Effect	-0.112	-0.441, 0.200	0.48
	Total Effect	0.139	-0.400, 0.678	0.60
	Proportion of Total Effect by mediation	-0.161	-1.625,1.400	0.70
WHI HA	Indirect Effect	0.014	-0.006, 0.049	0.22
	Direct Effect	0.737	0.320, 1.186	<0.01
	Total Effect	0.752	0.332, 1.193	<0.01
	Proportion of Total Effect by mediation	0.019	-0.008, 0.082	0.22

Indirect Effect/ACME (FTO→TSS→BMI); Direct Effect (FTO →BMI)