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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Brain Behav Immun. 2015 Nov 10;53:84–95. doi: 10.1016/j.bbi.2015.11.005

Figure 1. Overexpression of IL-17A in mouse brain.

Figure 1

(A) Three months after rAAV5-IL-17A intraventricular injection, IL-17A was identified as an approximate 16 kDa fragment in the brain homogenate by western blot using anti-Flag M2 antibody. (B and C) Five months after the injection, IL-17A expression was found throughout the hippocampi and partly in neocortexes along the ventricles and hippocampi in IL-17A-in-Brain mice (B) while no positive staining was found in PBS-in-Brain mice (C). Scale bars are 500µm. (D) Nine months after injection, the levels of IL-17A in the plasma from IL-17A-in-Brain and PBS-in-Brain mice were determined by ELISA. ## P< 0.001.