Figure 2. In vivo and ex vivo distribution of [11C]vorozole in the rat brain.
Adult male rats were injected with ~0.5mCi of [11C]vorozole and scanned in a microPET for 60 minutes (right column). The brains were removed, sliced in a tissue slicer and the slices photographed (leftmost column), dried and exposed to a phosphoimager screen for 40 minutes. (2nd column from left). Two animals were injected with letrozole prior to the administration of the radiotracer (blocking study, 3rd column from left).