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. Author manuscript; available in PMC: 2016 May 18.
Published in final edited form as: Int J Obes (Lond). 2015 Oct 5;40(3):434–442. doi: 10.1038/ijo.2015.200

Figure 6. Irisin is a key mediator that induces browning of WAT.

Figure 6

A. mRNAs of BAT and beige genes in visceral fat tissue. B. Visceral and subcutaneous adipose tissues were immunostained for UCP1 (brown color). The percentage of UCP1-positive cells to the number of fat cells examined is shown in the right panel. C. Adipocyte-derived stem cells were treated with 20 nM, recombinant irisin. This raised the expression of PGC-1α and UCP1. D. Conditioned media from C2C12 cultured muscle cells lacking myostatin, stimulated the mRNAs of expression of BAT genes in adipocyte-derived stem cells. E. When the C2C12 conditioned medium was treated with a neutralizing antibody to Fndc5, the mRNAs of BAT genes were suppressed. (Results are mean ± SEM; *; p<0.05 vs. PBS or control).

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