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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: J Cardiovasc Pharmacol. 2016 Mar;67(3):260–265. doi: 10.1097/FJC.0000000000000343

Figure 1.

Figure 1

Diagram of the NE infusion protocol. In paired studies, 6-lead ECGs were recorded in conscious naïve (n = 8) and HF (n = 7) rabbits. A 10 minute baseline period was followed by pretreatment with saline (vehicle, Veh) or the CaMKII inhibitor KN-93. After a 20 minute wash-in period, increasing doses of NE (1.56 – 25 μg/kg/min) were infused intravenously for 90 seconds at each dose. Once VT occurred, the infusion was stopped and the rabbit was monitored for a 10 minute recovery period to verify the return of sinus rhythm.