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. Author manuscript; available in PMC: 2017 Mar 7.
Published in final edited form as: Mol Pharm. 2016 Jan 22;13(3):809–818. doi: 10.1021/acs.molpharmaceut.5b00723

Figure 2.

Figure 2

M1 does not inhibit the hERG channel. The hERG assay was conducted using transfected Chinese Hamster Ovary (CHO)-hERG cells in an automated patch clamp study. Quinidine (closed squares) was used as a positive control. GraphPad Prism 6 was used to generate the best-fit, nonlinear line of regression (dotted line) to calculate its IC50 of 1.66 µM. The IC50 of M1 (closed circles) was higher than 25 µM. Values are an average of at least three replicates with corresponding standard deviation values (*p=0.01–0.05; **p=0.001–0.01; ***p< 0.0001).