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. Author manuscript; available in PMC: 2017 Mar 7.
Published in final edited form as: Mol Pharm. 2016 Jan 22;13(3):809–818. doi: 10.1021/acs.molpharmaceut.5b00723

Figure 3.

Figure 3

The ovarian cancer cell line, SK-OV-3, is susceptible to M1•ABZ treatment. SK-OV-3 cells were seeded at 5×105 cells/well overnight followed by 24h treatment with increasing concentrations of M1•ABZ. The Roche Cell Death ELISA® was performed to quantify apoptotic cell death. Staurosporine (1µM) was used as a positive control and the average of this control was set at a 100% apoptosis. The average (n=6) and standard deviation is shown. GraphPad Prism 6 was used to generate the best-fit line of regression (dotted line) to calculate the EC50 value of 3.2 µM for ABZ efficacy.