TABLE II.

Brighton Collaboration case definition of anaphylaxis¹²

For all levels of diagnostic certainty:

Anaphylaxis is a clinical syndrome characterized by

• sudden onset AND

• rapid progression of signs and symptoms AND

• multiple (≥2) organ systems, as follows:

Level 1 of diagnostic certainty

• ≥1 major dermatological AND

• ≥1 major cardiovascular AND/OR ≥1 major respiratory criterion

Level 2 of diagnostic certainty

• ≥ 1 major cardiovascular AND ≥1 major respiratory criterion

OR

• ≥1 major cardiovascular OR respiratory criterion AND

• ≥1 minor criterion involving ≥1 different system (other than     cardiovascular or respiratory systems)

• (≥1 major dermatologic) AND (≥1 minor cardiovascular AND/OR     minor respiratory criterion)

Level 3 of diagnostic certainty

• ≥1 minor cardiovascular OR respiratory criterion AND

• ≥1 minor criterion from each of ≥2 different systems/categories