TABLE III.

Major and minor criteria used in the case definition of anaphylaxis: Brighton Collaboration Criteria¹²

	Major criteria	Minor criteria
Dermatologic  or mucosal	Generalized urticaria (hives) or generalized erythema Angioedema,* localized or generalized Generalized pruritus with skin rash	Generalized pruritus without skin rash Generalized prickle sensation Localized injection-site urticaria Red and itchy eyes
Cardiovascular	Measured hypotension Clinical diagnosis of uncompensated shock indicated by the combination of >3 of the following: tachycardia capillary refill time >3 s reduced central pulse volume decreased level of consciousness or loss of consciousness	Reduced peripheral circulation, as indicated by the combination of ≥2 of the following: tachycardia and capillary refill time >3 s without hypotension decreased level of consciousness
Respiratory	Bilateral wheeze (bronchospasm) Stridor Upper airway swelling (lip, tongue, throat, uvula, or larynx) Respiratory distress, 2 or more of the following: tachypnea increased use of accessory muscles (eg, sternocleidomastoid and intercostals) recession cyanosis grunting	Persistent dry cough Hoarse voice Difficulty breathing without wheeze or stridor Sensation of throat closure Sneezing, rhinorrhea
Gastrointestinal		Diarrhea Abdominal pain Nausea Vomiting
Laboratory		Mast cell tryptase level increase > upper normal limit

^*Not hereditary angioedema.